October 5, 2020

Detoxification – It’s More Than Teas and Fasting

We are constantly exposed to toxins every single day, and our bodies work hard to detox 24/7. Today, let’s dive deeper into how our amazing bodies detoxify and the nutrients that can support that process.

Health Benefits of Detoxification

Our body is continually detoxing – 24 hours a day, 7 days a week. The liver is the primary organ of detoxification; however, every cell in the body has its own detox pathway. Detoxification occurs when lipophilic (fat-soluble) substances are converted to water-soluble substances. Detoxification is essential to the healthy function of our bodies. This is done through three stages known as Phase I, Phase II, and Phase III. Through these phases, toxins can be excreted through the body by breath, sweat, pee, or poo when they attach to a water molecule.

So what happens if toxins build up? We can begin to experience various symptoms. Symptoms are warning signs/messages that your body is giving you to let you know that something is not in balance within your body. So often, we, as in the general population, turn a deaf ear to these messages. It’s often not until your body is screaming that you begin to listen and seek out answers or make changes.

Signs of Toxic Overload

Systemic inflammation
Brain fog
Memory problems
Depression
Anxiety
Headache/migraine
Fatigue
Obesity
Infertility/miscarriage
Joint/muscle pain
Hormone imbalance
PMS
Allergies
Eczema
Chronic colds
Autoimmune condition

How to Detox

Well, our body is pretty dang smart. It recognizes toxins that we are exposed to outside of our body (exogenous toxins) and ones that are generated in our bodies (endogenous toxins), and it sends them through the detoxification process. However, sometimes our bodies cannot keep up with the demands we put on them. When that happens, toxins are stored in fatty tissue and in the liver. When you support your body’s detoxification pathway through nutrition, lifestyle, and possible supplements, you can begin to release these toxins. This happens during Phase I of detoxification.

Phase I Detoxification

Toxins are released from fat and functionalized to be more water-soluble. This occurs through enzyme reactions that result in oxidation, reduction, and hydrolysis. Now, this is where things can get complicated. You see, if those free radicals are not quickly neutralized by antioxidants or attached to a water molecule (Phase II), they can be recirculated into your system. These released toxins/free radicals are almost more dangerous than the original toxin.

Phase II Detoxification

Enzymatic conjugation occurs during Phase II to further increase water solubility and decrease the reactivity of Phase I products through 6 different pathways – sulfonation, glucuronidation, glutathione, acetylation, acylation, and methylation. Through this process, the toxins are attached to a water molecule and are now ready for Phase III.

Phase III Detoxification

This is the phase where we purge the toxins from our bodies. Elimination occurs through sweat (skin), breath (lungs), urine (kidneys), and feces (liver/GI tract). If any of these pathways are compromised, detoxification can be compromised.

How to Support Detoxification

In a perfect world, we would go through Phases I and II at the same rate of speed. However, we often see Phase I work well (toxin released and now a free radical) and Phase II be sluggish (attaches the free radical to a water molecule). This can be dangerous as free radicals can potentially be more dangerous than the original toxin. Damage can occur to the DNA, phospholipids, and proteins. Antioxidants are a must! To really support the Phase I and II pathways, we can turn to foods, herbs/supplements.

Phase I Detoxification Supporting Nutrients

aB-complex
Glutathione
Branch-chain amino acids
Antioxidants
- Carotenoids
- Vitamin C and E
- Glutathione
- Selenium and Zinc
- CoQ10
- Sulfur
- Bioflavonoids
- Milk thistle
- Proanthocyanidins

Foods containing these nutrients include (but may not be limited to):

Liver
Animal proteins
Seafood
Poultry
Mushrooms
Nuts
Seeds
Avocado
Legumes
Potatoes
Bananas
Leafy greens
Eggs
Bone Broth
Peppers
Squash
Carrots
Stone fruits
Berries
Whole grains
Olive oil
Tropical fruits
Cruciferous vegetables

Phase II Detoxification Supporting Nutrients

Sulfur-containing foods
Glutathione support
- Cysteine
- Glycine
- Glutamic acid
Taurine
- Animal proteins
- Seafood
- Poultry
- Eggs
Glutamine
- Bone Broth
- Animal proteins
- Spirulina
- Legumes
- Cruciferous veggies
Folate
- Liver
- Legumes
- Leafy Greens
- Asparagus
- Avocado
B12
- Seafood
- Liver
- Animal proteins
- Poultry
- Eggs
Choline

Phase III Detoxification Pathway Support

GI Tract

Bile is the primary route of detox metabolite excretion once the liver processes it. If you don’t have a gallbladder, your detoxification can be compromised. But don’t worry! You can supplement with ox bile to support that process.
Fiber acts as a sponge to toxins but also encourages bowel movements.
- Constipation can add to the toxic burden as toxins in the fecal material are reabsorbed into the bloodstream, the longer it sits in your GI tract. Bowel movements should occur daily. Ideally, you have 2-3 bowel movements per day that are soft and formed like a banana.
- Gut dysbiosis can compromise detoxification. H. pylori? Leaky gut? Candida? SIBO? These (and other gut issues) can impair the process. I would suggest addressing getting your microbiome in balance first.

Kidneys

Hydration, hydration, hydration. That toxin needs to attach to a water molecule to be excreted. Your kidneys are the main players in this whole process.

Sweating/Skin

Eccrine sweat glands are located all over the body, and apocrine sweat glands are located in the armpits and groin area. However, some skincare/personal care products can block pores from sweating and releasing those toxins. Reading labels and replacing ones with clean formulations is a very important step to holistic health. Here are some other key tips.
- Avoid aluminum in antiperspirants. It inhibits the flow of sweat from the glands to the skin surface.
- Avoid mineral oil/petroleum-based products. These are very occlusive and will not allow the skin to “breathe” or sweat appropriately.

Intense physical activity can increase sweating, which is good! But it also increases free radicals.
- Be sure to include antioxidants after workouts to neutralize those free radicals.
- Saunas can be an effective way to increase sweating without increasing free radicals.

Breath

Deep breathing techniques can help clear toxins. Deep breaths are also great for activating the parasympathetic nervous system. This is very important in our high-stress, busy world, as we are often operating on the sympathetic (fight or flight) nervous system.

Supplements and Herbs to Support Detoxification

You can also include herbs and supplements to support your detox pathways through elimination and bile production, protect the liver, and provide antioxidants.

Milk thistle
Artichoke
Turmeric
Dandelion root and leaf
Green tea
Burdock root
Celandine
Gentian

In addition to the nutrients and antioxidants listed to support Phase I and Phase II, these supplements can help provide targeted support when doing a focused detoxification.

N-Acetylcysteine (NAC) – upregulates glutathione
Lipoic acid – antioxidant
Phosphatidylcholine – increases liver clearance
Cracked cell chlorella – antioxidant
Activated charcoal – binds to toxins to prevent reabsorption (should not be taken within 1 hour of food, other supplements, or medications)

Targeted detoxification is a good thing to incorporate into your life a few times a year. Some like to do a detox at the change of every season to reset and refocus on health and wellness. When you are doing a targeted detox, there are a few foods that I recommend eliminating to really get the best benefit for your efforts and reduce inflammation.